Computed Tomography Scanning in Cystic Fibrosis Research Trials: Practical Lessons from Three Clinical Trials in the United States

Over the last 15 years, several clinical trials in subjects with cystic fibrosis (CF) have employed computed tomography (CT) scanning as an outcome surrogate. These research trials have increased our knowledge about the appearance of the lungs in patients with CF, and the relationship between the CT...

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Bibliographic Details
Published inProceedings of the American Thoracic Society Vol. 4; no. 4; pp. 350 - 354
Main Author Brody, A. S.
Format Journal Article
LanguageEnglish
Published United States 01.08.2007
Subjects
Adolescent
Adult
Child
Clinical Trials as Topic
Cystic Fibrosis - diagnosis
Cystic Fibrosis - diagnostic imaging
Gene Transfer Techniques
Humans
Middle Aged
Outcome Assessment (Health Care)
Purinergic P2 Receptor Agonists
Randomized Controlled Trials as Topic
Receptors, Purinergic P2Y2
Respiratory Function Tests
Tomography, X-Ray Computed
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Summary:Over the last 15 years, several clinical trials in subjects with cystic fibrosis (CF) have employed computed tomography (CT) scanning as an outcome surrogate. These research trials have increased our knowledge about the appearance of the lungs in patients with CF, and the relationship between the CT appearance, pulmonary function tests, and clinical outcomes. In addition, practical information has been gained on the use of CT scanning in CF research trials. In this article, practical issues on the use of CT scanning in CF clinical trials are presented and specific lessons from three of these trials are discussed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1546-3222
DOI:10.1513/pats.200611-182HT