Retinal vascular reactivity to norepinephrine and angiotensin II in normals and diabetics
Retinal vascular reactivity to norepinephrine and angiotensin II in normals and diabetics. F H Rhie , A R Christlieb , T Sandor , R E Gleason , L I Rand , S T Shah and J S Soeldner Abstract Retinal arterial vasoconstriction induced by an infusion of angiotensin II or norepinephrine was investigated...
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Published in | Diabetes (New York, N.Y.) Vol. 31; no. 12; pp. 1056 - 1060 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Diabetes Association
01.12.1982
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Subjects | |
Online Access | Get full text |
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Summary: | Retinal vascular reactivity to norepinephrine and angiotensin II in normals and diabetics.
F H Rhie ,
A R Christlieb ,
T Sandor ,
R E Gleason ,
L I Rand ,
S T Shah and
J S Soeldner
Abstract
Retinal arterial vasoconstriction induced by an infusion of angiotensin II or norepinephrine was investigated in eight normal
controls (N), nine diabetics without retinopathy (DNR), and 10 diabetics with retinopathy (DR) by color fundus photographs
taken before and after the infusions. Image analysis was done by a semiautomated computerized microdensitometer using a videoscanner.
Normal controls and diabetics without retinopathy had a significant reduction in diameter compared with diabetics with retinopathy,
who failed to constrict arterioles in response to either vasopressor. The mechanism of this phenomenon is unclear. Semiautomated
computerized microdensitometry is reproducible and appears to be a sensitive technique to evaluate the vascular reactivity
of the retinal vasculature. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0012-1797 1939-327X 0012-1797 |
DOI: | 10.2337/diabetes.31.12.1056 |