Niobium pentachloride promoted conversion of carboxylic acids to carboxamides: Synthesis of the 4-aryl-1,2,3,4-tetrahydroisoquinoline alkaloid structures

A practical method for the conversion of carboxylic acids to the corresponding carboxamides mediated by niobium pentachloride under mild conditions is described. The synthesis of the 4-aryl-1,2,3,4-tetrahydroisoquinoline alkaloid structures was accomplished via benzylic lithiation of N-methyl-3,4-di...

Full description

Saved in:
Bibliographic Details
Published inSynthesis (Stuttgart) no. 2; pp. 272 - 276
Main Authors Nery, MS, Ribeiro, RP, Lopes, CC, Lopes, RSC
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.01.2003
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
CHERYLLINE
tetrahydroisoquinoline
niobium pentachloride
carboxamides
alkaloid
carboxylic acids
Online AccessGet more information

Cover

More Information
Summary:A practical method for the conversion of carboxylic acids to the corresponding carboxamides mediated by niobium pentachloride under mild conditions is described. The synthesis of the 4-aryl-1,2,3,4-tetrahydroisoquinoline alkaloid structures was accomplished via benzylic lithiation of N-methyl-3,4-dimethoxy-2(4'-methoxybenzyl)benzamide.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2003-36823