Neuroimaging manifestations of paediatric histiocytoses

Summary Histiocytoses are rare multi‐system disorders marked by abnormal histiocyte cell proliferation, affecting children with diverse clinical presentations. Classified into five groups in 2016, including Langerhans‐related (L), cutaneous (C), malignant (M), Rosai–Dorfman disease (R) and haemophag...

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Published inJournal of medical imaging and radiation oncology
Main Authors Tan, Hsern Ern Ivan, Lakshmanan, Rahul, Warne, Richard, Walwyn, Thomas, Roebuck, Derek
Format Journal Article
LanguageEnglish
Published 14.11.2023
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Abstract Summary Histiocytoses are rare multi‐system disorders marked by abnormal histiocyte cell proliferation, affecting children with diverse clinical presentations. Classified into five groups in 2016, including Langerhans‐related (L), cutaneous (C), malignant (M), Rosai–Dorfman disease (R) and haemophagocytic lymphohistiocytosis (H), newer entities such as ALK‐positive histiocytosis have also emerged, heralding the era of molecular (sub)classification. Common entities include Langerhans cell histiocytosis (LCH), Erdheim–Chester disease (ECD), Rosai–Dorfman disease (RDD) and haemophagocytic lymphohistiocytosis (HLH). This pictorial essay aids radiologists in recognising and differentiating paediatric histiocytoses based on unique neuroimaging features.
AbstractList Histiocytoses are rare multi-system disorders marked by abnormal histiocyte cell proliferation, affecting children with diverse clinical presentations. Classified into five groups in 2016, including Langerhans-related (L), cutaneous (C), malignant (M), Rosai-Dorfman disease (R) and haemophagocytic lymphohistiocytosis (H), newer entities such as ALK-positive histiocytosis have also emerged, heralding the era of molecular (sub)classification. Common entities include Langerhans cell histiocytosis (LCH), Erdheim-Chester disease (ECD), Rosai-Dorfman disease (RDD) and haemophagocytic lymphohistiocytosis (HLH). This pictorial essay aids radiologists in recognising and differentiating paediatric histiocytoses based on unique neuroimaging features.
Summary Histiocytoses are rare multi‐system disorders marked by abnormal histiocyte cell proliferation, affecting children with diverse clinical presentations. Classified into five groups in 2016, including Langerhans‐related (L), cutaneous (C), malignant (M), Rosai–Dorfman disease (R) and haemophagocytic lymphohistiocytosis (H), newer entities such as ALK‐positive histiocytosis have also emerged, heralding the era of molecular (sub)classification. Common entities include Langerhans cell histiocytosis (LCH), Erdheim–Chester disease (ECD), Rosai–Dorfman disease (RDD) and haemophagocytic lymphohistiocytosis (HLH). This pictorial essay aids radiologists in recognising and differentiating paediatric histiocytoses based on unique neuroimaging features.
Author Walwyn, Thomas
Warne, Richard
Tan, Hsern Ern Ivan
Lakshmanan, Rahul
Roebuck, Derek
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  organization: Department of Medical Imaging Perth Children's Hospital Perth Western Australia Australia, Department of Medical Imaging Fiona Stanley Hospital Perth Western Australia Australia
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  givenname: Rahul
  surname: Lakshmanan
  fullname: Lakshmanan, Rahul
  organization: Department of Medical Imaging Perth Children's Hospital Perth Western Australia Australia, University of Western Australia Perth Western Australia Australia
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  surname: Warne
  fullname: Warne, Richard
  organization: Department of Medical Imaging Perth Children's Hospital Perth Western Australia Australia
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  fullname: Walwyn, Thomas
  organization: University of Western Australia Perth Western Australia Australia, Department of Oncology Perth Children's Hospital Perth Western Australia Australia
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  givenname: Derek
  surname: Roebuck
  fullname: Roebuck, Derek
  organization: Department of Medical Imaging Perth Children's Hospital Perth Western Australia Australia, University of Western Australia Perth Western Australia Australia
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Snippet Summary Histiocytoses are rare multi‐system disorders marked by abnormal histiocyte cell proliferation, affecting children with diverse clinical presentations....
Histiocytoses are rare multi-system disorders marked by abnormal histiocyte cell proliferation, affecting children with diverse clinical presentations....
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Title Neuroimaging manifestations of paediatric histiocytoses
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