Neuroimaging manifestations of paediatric histiocytoses

Summary Histiocytoses are rare multi‐system disorders marked by abnormal histiocyte cell proliferation, affecting children with diverse clinical presentations. Classified into five groups in 2016, including Langerhans‐related (L), cutaneous (C), malignant (M), Rosai–Dorfman disease (R) and haemophag...

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Bibliographic Details
Published inJournal of medical imaging and radiation oncology
Main Authors Tan, Hsern Ern Ivan, Lakshmanan, Rahul, Warne, Richard, Walwyn, Thomas, Roebuck, Derek
Format Journal Article
LanguageEnglish
Published 14.11.2023
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Summary:Summary Histiocytoses are rare multi‐system disorders marked by abnormal histiocyte cell proliferation, affecting children with diverse clinical presentations. Classified into five groups in 2016, including Langerhans‐related (L), cutaneous (C), malignant (M), Rosai–Dorfman disease (R) and haemophagocytic lymphohistiocytosis (H), newer entities such as ALK‐positive histiocytosis have also emerged, heralding the era of molecular (sub)classification. Common entities include Langerhans cell histiocytosis (LCH), Erdheim–Chester disease (ECD), Rosai–Dorfman disease (RDD) and haemophagocytic lymphohistiocytosis (HLH). This pictorial essay aids radiologists in recognising and differentiating paediatric histiocytoses based on unique neuroimaging features.
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ISSN:1754-9477
1754-9485
DOI:10.1111/1754-9485.13602