A new catch-and-release purification method using a 4-azido-3-chlorobenzyl group

Products that possess 4-azido-3-chlorobenzyl group were selectively isolated from reaction mixtures by using a solid-supported phosphine. Successive treatment with 2,3-dichloro-5,6-dicyanobenzoquinone readily liberated purified products. Application of this method to several oligosaccharide synthese...

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Bibliographic Details
Published inSynlett no. 6; pp. 777 - 780
Main Authors Egusa, K, Kusumoto, S, Fukase, K
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 2001
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
phosphines
SOLID-PHASE SYNTHESIS
STRATEGY
AFFINITY PURIFICATION
GLYCOSYLATION
azides
SUPPORTED SOLUTION SYNTHESIS
glycosylations
polymer-supported synthesis
ETHER
CONSTRUCTION
OLIGOSACCHARIDE SYNTHESIS
COMBINATORIAL
combinatorial chemistry
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Summary:Products that possess 4-azido-3-chlorobenzyl group were selectively isolated from reaction mixtures by using a solid-supported phosphine. Successive treatment with 2,3-dichloro-5,6-dicyanobenzoquinone readily liberated purified products. Application of this method to several oligosaccharide syntheses is described.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2001-14623