Association between pemphigus and psoriasis: a systematic review and meta-analysis

Pemphigus has been associated with other autoimmune and autoinflammatory disorders. Specifically, some case reports in the literature document coexistence of pemphigus with psoriasis, but this association is lacking larger scale investigation. With this in mind, we conducted a systematic review and...

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Bibliographic Details
Published inDermatology online journal Vol. 26; no. 8
Main Authors Phan, Kevin, Ramachandran, Vignesh, Smith, Saxon D
Format Journal Article
LanguageEnglish
Published United States University of California Digital Library - eScholarship 15.08.2020
Subjects
Humans
Pemphigus - complications
Pemphigus - physiopathology
Psoriasis
Psoriasis - complications
Psoriasis - physiopathology
Systematic review
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Summary:Pemphigus has been associated with other autoimmune and autoinflammatory disorders. Specifically, some case reports in the literature document coexistence of pemphigus with psoriasis, but this association is lacking larger scale investigation. With this in mind, we conducted a systematic review and meta-analysis to evaluate the association between pemphigus and psoriasis. In doing so, we found an association between the two conditions. Pemphigus was more common in patients with psoriasis than in controls (OR 2.64, 95% CI 1.24-5.59, P=0.01), with heterogeneity (I2=94%). We go on to propose pathophysiologic mechanisms and its relevance for diagnostic and management considerations.
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ISSN:1087-2108
1087-2108
DOI:10.5070/D3268049899