The inhibitory effect of bis(2-((E)-2-octenoylamino)ethyl) disulfide on the cyclooxygenase pathway

Bis(2-((E)-2-octenoylamino)ethyl) disulfide (compd. I-3) inhibited collagen- and arachidonic acid-induced rat platelet aggregation, although not adenosine 5'-diphosphate (ADP)-induced rat platelet aggregation. Based on these results, the authors then investigated the inhibitory effect of compd....

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Published inChemical & pharmaceutical bulletin Vol. 37; no. 3; pp. 778 - 780
Main Authors MIMURA, Tsutomu, NAKAJIMA, Hiroshi, TSUJIKAWA, Kazutake, YASUDA, Naohiro, HARUYAMA, Munetada, OKABE, Masaru, IWAI, Masakazu, YOKOYAMA, Kazumasa
Format Journal Article
LanguageEnglish
Published 1989
Subjects
platelets
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Summary:Bis(2-((E)-2-octenoylamino)ethyl) disulfide (compd. I-3) inhibited collagen- and arachidonic acid-induced rat platelet aggregation, although not adenosine 5'-diphosphate (ADP)-induced rat platelet aggregation. Based on these results, the authors then investigated the inhibitory effect of compd. I-3 on thromboxane B sub(2) formation from arachidonic acid in rat platelets, and prostaglandin I sub(2) formation in rat aortae. The findings suggested that compd. I-3 has an inhibitory effect on cyclooxygenase activity, like non-steroidal anti-inflammatory drugs.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.37.778