Pre-clinical testing of different implant structures in animal subjects

• Published in: IOP conference series. Materials Science and Engineering Vol. 776; no. 1; pp. 12108 - 12115
• Main Authors: Mitrík, L, Trebuňová, M, Hudák, R, Schnitzer, M, Živčák, J
• Format: Journal Article
• Language: English
• Published: Bristol IOP Publishing 01.02.2020
• Subjects: Admixtures; Biomedical materials; Case studies; Surgical implants; Testing and certification; Transplants & implants
• ISSN: 1757-8981; 1757-899X
• DOI: 10.1088/1757-899X/776/1/012108

The aim of this study was to develop a methodology of preclinical animal testing in case studies for implants with PEEK material and its derivatives with possible use for other materials. In the theoretical part, the study deals with the analysis of the current situation in the area of preclinical animal testing, especially in the field of implantology. Based on this analysis, the test implant structures were prepared at the workplace, which were subsequently inserted into appropriate rabbit individuals by surgical intervention in case studies. These case studies serve to create a comprehensive test methodology for animal preclinical tests within a statistically relevant animal sample for the needs of subsequent clinical testing and certification of the biomaterial used. These studies confirmed that the proportion of ceramic admixture elements in PEEK promoted the growth of bone tissue.