Genetic diversity of feline leukemia virus

Feline Leukemia Virus (FeLV) belongs to retrovirus family, causing various proliferative and immunosuppressive diseases in felines. There are two forms of FeLV: endogenous (enFeLV) and exogenous (exFeLV), the latter has 4 subgroups: A, B, C and T with different receptor specificity. The FeLV-A is th...

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Published inIOP conference series. Earth and environmental science Vol. 315; no. 4; pp. 42038 - 42041
Main Authors Komina, A K, Zaberezhny, A D, Kucheruk, O D, Zhukova, E V, Guliukina, I A
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 01.08.2019
Subjects
Cats
Domestic animals
Feline leukemia
Genetic diversity
Leukemia
Mutation
Recombination
Subgroups
Viruses
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Summary:Feline Leukemia Virus (FeLV) belongs to retrovirus family, causing various proliferative and immunosuppressive diseases in felines. There are two forms of FeLV: endogenous (enFeLV) and exogenous (exFeLV), the latter has 4 subgroups: A, B, C and T with different receptor specificity. The FeLV-A is the most abundant transmissive form. The FeLVB emerged as a recombinant between provirus FeLV-A and endogenous virus of domestic cats. The FeLV-C appeared as a result of accumulation of mutations in the env FeLV-A gene. The chimeric FeLV-T virus was obtaind as recombination event between 61E and 61C viruses. This review also covers two new recently described subgroups - FeLV-D и TG35.
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ISSN:1755-1307
1755-1315
DOI:10.1088/1755-1315/315/4/042038