Ethyl 3-(4-fluorophenyl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydrofuro[2,3- d ]pyrimidine-5-carboxylate

In the crystal structure of the title compound, C22H24FN3O4, the two fused rings of furo[2,3-d]pyrimidine form a dihedral angle of 0.88 (13)°. The attached benzene ring is twisted with respect to the heterocyclic pyrimidinone ring, making a dihedral angle of 75.07 (12)°. The cyclohexyl ring shows a...

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Published inActa crystallographica. Section E, Structure reports online Vol. 64; no. 1; pp. o311 - o312
Main Authors Sun, Yong, Zeng, Guo-Ping, Hu, Yang-Gen
Format Journal Article
LanguageEnglish
Published International Union of Crystallography 2008
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Summary:In the crystal structure of the title compound, C22H24FN3O4, the two fused rings of furo[2,3-d]pyrimidine form a dihedral angle of 0.88 (13)°. The attached benzene ring is twisted with respect to the heterocyclic pyrimidinone ring, making a dihedral angle of 75.07 (12)°. The cyclohexyl ring shows a distorted chair conformation. The molecular structure is stabilized by intramolecular C-H...O and C-H...N hydrogen-bonding interactions. The crystal packing is mainly stabilized by C-H...π hydrogen-bond interactions. Further stability is provided by C-F...π and C-O...π stacking interactions.
ISSN:1600-5368
1600-5368
DOI:10.1107/S1600536807066780