Rosai-Dorfman disease mimicking images of meningiomas: Two case reports and literature review

• Published in: Surgical neurology international Vol. 12; p. 292
• Main Authors: Tatit, Rafael Trindade, Raffa, Paulo Eduardo Albuquerque Zito, de Almeida Motta, Giovana Cassia, Bocchi, André Alexandre, Guimaraes, Júlia Loripe, Franceschini, Paulo Roberto, de Aguiar, Paulo Henrique Pires
• Format: Journal Article
• Language: English
• Published: United States Scientific Scholar 21.06.2021
• Subjects: Case Report; Magnetic resonance imaging; Histiocytosis; Meningioma; Central nervous system; Rosai-Dorfman disease
• ISSN: 2229-5097; 2152-7806; 2152-7806
• DOI: 10.25259/SNI_918_2020

Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytic proliferative disorder classically as a massive cervical lymphadenopathy. However, over the years, extranodal locations were confirmed with the central nervous system involvement in less than 5% of cases, which is marked as a significant differential diagnosis of meningiomas, with which they are widely confused due to the similarity of their radiological images. We report a 37-year-old man and 45-year-old man who were diagnosed with intracranial RDD but whose radiological images mimic meningiomas, requiring anatomopathological and tumor's immunohistochemistry for definitive diagnosis. Moreover, a review of 184 publications with 285 cases of intracranial involvement of this disease was also performed, comparing these findings with those brought in the previous studies. Intracranial Rosai-Dorfman tumors should always be remembered as differential diagnosis of meningiomas since they are similar radiologically and macroscopically. Once remembered and diagnosed, the lesion must be treated following the same pattern of resection done in meningiomas and, treatment's differences will not occur in the surgical excision technique, but in complementary chemotherapy implementation, radiotherapy, and even with radiosurgery aid, depending on the case. Thus, it is possible to obtain better results than with just the isolated surgical procedure.