Modelisation, Synthesis and Anti-HIV activities of N,N,N′,N″,N‴-pentakistetraazamacrocycles salts derivatives

The syntheses and the anti-HIV activities of new N,N,N′,N″,N‴-pentakistetraazamacrocyles salts analogues are described. From computer modeling studies, it was found that zinc coordination capacity of these pentakis derivatives was larger than the one of the corresponding tetrakis analogues. This sug...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 7; no. 10; pp. 1353 - 1358
Main Authors Trabaud, C, Dessolin, J, Vlieghe, P, Bouygues, M, Chermann, J.C, Camplo, M, Kraus, J.L
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 20.05.1997
Elsevier
Subjects
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
Organic cation
HIV-1 virus
Nitrogen crown compound
Nitrogen heterocycle
Retroviridae
In vitro
Modeling
Macrocycle
Virus
Quaternary ammonium compound
Structure activity relation
Molecular model
Lentivirinae
Antiviral
Human immunodeficiency virus
Chemical synthesis
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Summary:The syntheses and the anti-HIV activities of new N,N,N′,N″,N‴-pentakistetraazamacrocyles salts analogues are described. From computer modeling studies, it was found that zinc coordination capacity of these pentakis derivatives was larger than the one of the corresponding tetrakis analogues. This suggest that a metal chelation energy could be a criteria to design novel anti-HIV polyazamacrocyles. © 1997 Elsevier Science Ltd.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(97)00222-9