Initial computed tomography findings of invasive pulmonary aspergillosis in non-hematological patients

• Published in: Chinese medical journal Vol. 125; no. 17; pp. 2979 - 2985
• Main Authors: Xu, Si-Cheng, Qiu, Li-Hua, Liu, Wen-Ya, Feng, Yu-Lin
• Format: Journal Article
• Language: English
• Published: China Intensive Care Unit,Radiology Center,First Affiliated Hospital,Xinjiang Medical University,Urumqi,Xinjiang 830054,China%Huaxi MR Research Center(HMRRC),Department of Radiology ,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China%CT Unit ,Radiology Center,First Affiliated Hospital,Xinjiang Medical University,Urumqi,Xinjiang 830054,China%Huaxi MR Research Center(HMRRC),Department of Respiratory Medicine ,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China 05.09.2012
• Subjects: Adolescent; Adult; Aged; CT图像; Female; Humans; Invasive Pulmonary Aspergillosis - diagnostic imaging; Invasive Pulmonary Aspergillosis - pathology; IPA; Male; Middle Aged; Retrospective Studies; Tomography, X-Ray Computed - methods; 侵袭性; 急性支气管肺炎; 曲霉病; 空间整合; 血液病; 计算机断层扫描; computed tomography scan; immunosuppression; fungal lung disease; invasive pulmonary aspergillosis
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.2012.17.004

Background The computed tomography （CT） findings of invasive pulmonary aspergillosis （IPA） are unclear in non- hematological patients. The present study was a retrospective evaluation of CT images in non-hematological patients with IPA. Methods All adult patients who met the 2008 European Organization for Research and Treatment of Cancer/Mycoses Study Group （EORTC/MSG） criteria for proven or probable IPA were included during a 5-year study at our institutions. Initial CT findings in our cohort were retrospectively reviewed by two independent thoracic radiologists blinded to patient demographics and clinical outcomes. The presence, pattern, and distribution of abnormalities were recorded. Results Twenty-three non-hematological patients with pathologically confirmed IPA were included in our study. Areas of ground-glass opacities were present in 14 patients （61%）, which were bilateral in 10 patients and unilateral in four. This pattern mainly involved the middle and upper lung zones. Air-space consolidation was identified in 12 patients （52%）, and the areas were distributed along the bronchus or subpleura in most cases. Other findings, including five small nodules （22%）, three macronodules （13%）, and one halo sign （4%）, were less common. Conclusions CT findings of IPA in non-hematological patients frequently manifested as acute bronchopneumonia, and ground-glass opacities and air-space consolidations were the most common CT findings of IPA in these patients.