Evaluation of Cell Viability in Living Tissue Equivalents Exposed to Pulsed Current with a DC Offset

An electrophysical apparatus for combined electroporation and iontophoresis treatment of biological membranes is described. Estimates of cell viability in living tissue equivalents exposed to pulsed current with a dc offset are provided. The values of the electrophysical pulse characteristics compat...

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Bibliographic Details
Published inTechnical physics letters Vol. 47; no. 9; pp. 681 - 684
Main Authors Shershunova, E. A., Rebrov, I. E., Mishchenko, V. V., Kryukov, A. I., Vorotelyak, E. A., Rogovaya, O. S.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.09.2021
Springer Nature B.V
Subjects
Classical and Continuum Physics
Cochlea
Electric fields
Electroporation
Equivalence
Membranes
Physics
Physics and Astronomy
Pulsed current
Tissues
Transportation applications
biological membranes
pulsed current
cell viability
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Summary:An electrophysical apparatus for combined electroporation and iontophoresis treatment of biological membranes is described. Estimates of cell viability in living tissue equivalents exposed to pulsed current with a dc offset are provided. The values of the electrophysical pulse characteristics compatible with the viability of cells in the living tissue equivalents have been determined. The obtained data suggest that these electrophysical parameters could be used for transportation of pharmaceutical compounds through an equivalent of the round window membrane of the cochlea. A technique of drug administration across biological barriers can be developed based on pulsed electric field equipment to enable drug delivery into the inner ear.
ISSN:1063-7850
1090-6533
DOI:10.1134/S1063785021070130