C(5)—H arylation of 1-substituted 1,2,4-triazoles with aryl halides under Pd/NHC catalysis

An efficient method for the synthesis of 1-substituted 5-aryl-1,2,4-triazoles by selective C—H arylation of 1-substituted 1,2,4-triazoles with non-activated aryl chlorides and aryl bromides under the catalysis by a palladium complex with a N-heterocyclic carbene ligand IPr *OMe using 1,1,2,2-tetraph...

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Bibliographic Details
Published inRussian chemical bulletin Vol. 73; no. 4; pp. 950 - 956
Main Authors Astakhov, A. V., Chernenko, A. Yu, Kutyrev, V. V., Chernyshev, V. M.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.04.2024
Springer Nature B.V
Subjects
Aromatic compounds
Bromides
Catalysis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Full Articles
Halides
Inorganic Chemistry
Organic Chemistry
Palladium
Substitutes
Triazoles
palladium
1,2,4-triazole
C—H arylation
N-heterocyclic carbenes
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Summary:An efficient method for the synthesis of 1-substituted 5-aryl-1,2,4-triazoles by selective C—H arylation of 1-substituted 1,2,4-triazoles with non-activated aryl chlorides and aryl bromides under the catalysis by a palladium complex with a N-heterocyclic carbene ligand IPr *OMe using 1,1,2,2-tetraphenylethane-1,2-diol (TPEDO) as a catalyst activator is reported.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-024-4207-9