Effect of the Synthetic Peptide LKEKK on Psoriasis

It has been established that the synthetic peptide LKEKK affects the ability of IL-12 to control the secretory activity of keratinocytes isolated from psoriatic human skin: in the concentration range of 100–1000 nM, it enhanced in a dose-dependent manner IL-12-induced production of IL-10 and IFN-γ a...

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Bibliographic Details
Published inRussian journal of bioorganic chemistry Vol. 49; no. 6; pp. 1346 - 1352
Main Authors Navolotskaya, E. V., Sadovnikov, V. B., Zinchenko, D. V., Murashev, A. N.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.11.2023
Springer Nature B.V
Subjects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
In vivo methods and tests
Life Sciences
Organic Chemistry
peptides
cytokines
receptors
drugs
proteins
psoriasis
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Summary:It has been established that the synthetic peptide LKEKK affects the ability of IL-12 to control the secretory activity of keratinocytes isolated from psoriatic human skin: in the concentration range of 100–1000 nM, it enhanced in a dose-dependent manner IL-12-induced production of IL-10 and IFN-γ and inhibition of IL-17 secretion in vitro . The peptide with the inverted KKEKL sequence was inactive, indicating a high specificity of the action of the LKEKK peptide. The in vivo study of the activity of the LKEKK peptide in a mouse model of imiquimod-induced psoriasis showed that the daily application of 150–500 μg of the peptide together with Aldara cream containing 5% imiquimod on the ear for 6 days significantly suppressed the development of the inflammatory process. Thus, the LKEKK peptide is suitable as a basis for the development of drugs for treatment of psoriasis and other inflammatory skin diseases.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162023060158