Influence of pore sizes in 3D-scaffolds on mechanical properties of scaffolds and survival, distribution, and proliferation of human chondrocytes

Articular cartilage has weak intrinsic self-healing capacity. Tissue engineering is an appropriate option for cartilage regeneration. This research was designed to evaluate the effects of pore size in scaffolds on mechanical properties and chondrocyte-scaffold interactions. PCL scaffolds were fabric...

Full description

Saved in:
Bibliographic Details
Published inMechanics of advanced materials and structures Vol. 29; no. 26; pp. 4911 - 4922
Main Authors Abpeikar, Zahra, Milan, Peiman Brouki, Moradi, Lida, Anjomshoa, Maryam, Asadpour, Shiva
Format Journal Article
LanguageEnglish
Published Abingdon Taylor & Francis 26.10.2022
Taylor & Francis Ltd
Subjects
Cartilage
Cartilage tissue engineering
Mechanical properties
Mechanical tests
polycaprolactone
Pore size
scaffold
Scaffolds
Tissue engineering
Online AccessGet full text

Cover

More Information
Summary:Articular cartilage has weak intrinsic self-healing capacity. Tissue engineering is an appropriate option for cartilage regeneration. This research was designed to evaluate the effects of pore size in scaffolds on mechanical properties and chondrocyte-scaffold interactions. PCL scaffolds were fabricated with large, medium, and small pore sizes. The constructs were analyzed by SEM, swelling tests, mechanical tests, MTT assay, and H&E staining after chondrocyte seeding. Mechanical features of the scaffolds were near to human articular cartilage. Our findings suggest that the PCL scaffold with medium pore sizes provides suitable mechanical strength and better chondrocyte-scaffold interactions simultaneously for application in cartilage.
ISSN:1537-6494
1537-6532
DOI:10.1080/15376494.2021.1943077