A Painful Question about Genomic Coding of the Body Plan

One of the goals of developmental genetics is to decipher the anatomy of organisms from their genome. The study of Drosophila homeotic mutants has shown that individual elements of the anatomy can have clear genomic correlates. However, we are still far from a complete solution for this problem. Thi...

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Bibliographic Details
Published inPaleontological journal Vol. 57; no. 11; pp. 1257 - 1262
Main Authors Nikitin, M. A., Aleshin, V. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.12.2023
Springer Nature B.V
Subjects
Anatomy
Developmental genetics
Drosophila
Earth and Environmental Science
Earth Sciences
Genetics
Genomes
Genomics
Localization
Paleontology
Regulatory sequences
Transgenic animals
deep homology
body plans
homeobox genes
developmental genes
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Summary:One of the goals of developmental genetics is to decipher the anatomy of organisms from their genome. The study of Drosophila homeotic mutants has shown that individual elements of the anatomy can have clear genomic correlates. However, we are still far from a complete solution for this problem. This review analyzes the reasons why, despite a very rapid accumulation of genomic data, progress is very slow in this area. These causes are primarily determined by a large number of neutral changes (changes that do not influence the morphology) in the regulatory regions of the genome, as well as by the localization of evolutionarily important changes in noncoding regions of the genome. Therefore, it is particularly important to carry out an experimental verification of the functional role of genetic differences using crossing or methods for obtaining transgenic animals.
ISSN:0031-0301
1555-6174
DOI:10.1134/S0031030123110096