Complications in paediatric liver transplant from Kuwait when transplanted abroad

• Published in: Arab journal of gastroenterology Vol. 13; no. 4; pp. 178 - 179
• Main Authors: Al-Khalidi, Jameela A.S.J., Alenezi, Bader, Al-Qabandy, Wafa, Abo-Hamra, Eman, Husain, Khalid, Askar, Haifa A., Jagannathan, Ayyampalayam P., Abu-El-Naga, Hisham, Neff, Guy W.
• Format: Journal Article
• Language: English
• Published: Egypt Elsevier Ltd 01.12.2012
• Subjects: Acute cellular rejection; Adolescent; Biliary Atresia - drug therapy; Biliary Atresia - mortality; Biliary Atresia - surgery; Child; Child, Preschool; Chronic rejection/ductopenia; Combined Modality Therapy; Cyclosporine - adverse effects; Cyclosporine - therapeutic use; Female; Humans; Immunosuppressive Agents - adverse effects; Immunosuppressive Agents - therapeutic use; Infant; Kuwait; Liver Diseases - drug therapy; Liver Diseases - mortality; Liver Diseases - surgery; Liver Transplantation; Male; Paediatric liver transplantation; Patient Transfer; Postoperative Complications; Retrospective Studies; Treatment Outcome; Kuwait; ACR; LTx; Paediatric liver transplantation; PTLD; LRLT; Acute cellular rejection; Liver transplantation; Chronic rejection/ductopenia
• ISSN: 1687-1979; 2090-2387
• DOI: 10.1016/j.ajg.2012.08.011

Since the introduction of liver transplantation (LTx) in children suffering from liver failure in 1963, many centres around the world have offered this service to children that have no other alternative. The aim of this retrospective study is to analyse the results of paediatric liver transplant in Kuwait over the last decade. A retrospective chart review was done involving paediatric patients during the time period of 1995–2004. The information collected included patient demographics, indications for liver transplantation, survival of both patient and allograft, and complications. A total of 16 cases were found and analysed. The mean age was 3.6years (ranged 5months–17years). There were nine boys and seven girls. The most common indications for LTx were biliary atresia and metabolic liver disease. All the liver transplants were done abroad. There were totally nine deceased donor and seven living related cases. The complications were acute cellular rejection in five, hypertension in two, biliary complications in four, cytomegalovirus (CMV) infection in three and post lymphoproliferative disease in two cases. All but one patient are presently alive. The above information demonstrates that LTx in Kuwati children is safe and improves the quality of life for those that would otherwise have no other alternative.