Role of Nitric Oxide and Hydrogen Sulfide in Neuronal and Glial Cell Death in Neurodegenerative Processes

• Published in: Biochemistry (Moscow). Supplement series A, Membrane and cell biology Vol. 17; no. 4; pp. 223 - 242
• Main Authors: Rodkin, S. V., Nwosu, C. D.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.12.2023; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Cell Biology; Cell death; Glial cells; Hydrogen sulfide; Life Sciences; Mental disorders; Nervous system; Neurodegeneration; Neurodegenerative diseases; Neuronal-glial interactions; Neurons; Neuroprotection; Nitric oxide; Pathogenesis; Peripheral nervous system; Reviews; Structure-function relationships; glial cells; nitric oxide; autophagy; hydrogen sulfide; neurodegeneration; apoptosis; axotomy; neurons; oxidative stress
• ISSN: 1990-7478; 1990-7494
• DOI: 10.1134/S1990747823050069

— Neurodegeneration is a complex progressive pathological process leading to the neuronal death, which is induced by various external and internal factors. Neurodegenerative diseases, injuries of the central and peripheral nervous system, mental disorders, and a number of other pathological conditions, accompanied by functional and structural degradation of neurons and their death, is a serious problem in the global healthcare system, as due to these diseases millions of people around the world become disabled or die every year. The situation is complicated by the lack of selective, clinically effective neuroprotective drugs. It has been shown that nitric oxide (NO) and hydrogen sulfide (H 2 S) are actively involved in neurodegeneration and cell death of neurons and glia, but their role is not completely clear. This review considers NO- and H 2 S-dependent signaling mechanisms underlying the pathogenesis of neurodegenerative processes. The prospects for further studies of the role of NO and H 2 S in the nervous tissue under conditions of pathological conditions associated with neurodegeneration are considered.