Synthesis of 5-(5-amino-1H-pyrazol-1-yl)-1,2,3-thiadiazole-4-carboxylic acid ethyl esters and their cyclization into pyrazolo[1,5-a][1,2,3]thiadiazolo[4,5-e]pyrimidin-4(5H)-ones

A method for the synthesis of novel 1 H -pyrazol-1-yl-1,2,3-thiadiazole derivatives has been proposed and their intramolecular cyclization to pyrazolo[1,5- a ][1,2,3]thiadiazolo[4,5- e ]pyrimidin-4(5 H )-ones, previously unknown fused tricyclic heterocycles, has been studied.

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Bibliographic Details
Published inChemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 54; no. 11; pp. 1079 - 1082
Main Authors Vysokova, Olga А., Kalinina, Tatiana A., Slepukhin, Pavel А., Pospelova, Tatiana А., Obydennov, Konstantin L., Glukhareva, Tatiana V.
Format Journal Article
LanguageEnglish
Published New York Springer US 15.11.2018
Springer Nature
Springer Nature B.V
Subjects
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Esters
Ethyl esters
Organic Chemistry
Pharmacy
Physical Sciences
Science & Technology
Synthesis
Thiadiazoles
X-ray structural analysis
pyrimidin-4
pyrazolo[1,5
1,2,3-thiadiazoles
condensation
ones
pyrazoles
pyrimidines
fused heterocycles
tricyclic heterocycles
DESIGN
pyrazolo[1,5-a]pyrimidines
pyrimidin-4(3H)-ones
IDENTIFICATION
DISCOVERY
PARP-1 INHIBITORS
DERIVATIVES
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Summary:A method for the synthesis of novel 1 H -pyrazol-1-yl-1,2,3-thiadiazole derivatives has been proposed and their intramolecular cyclization to pyrazolo[1,5- a ][1,2,3]thiadiazolo[4,5- e ]pyrimidin-4(5 H )-ones, previously unknown fused tricyclic heterocycles, has been studied.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-018-2396-6