Analysis of Metabolic Pathways in Intrauterine Growth Restriction

— The analysis of metabolic pathways of amino acids during fetal intrauterine growth restriction (IUGR) was performed on the basis of the study of the metabolomic profile in pregnant women. This analysis revealed pathways, ordered according to the levels of confidence (analysis of pathways enrichmen...

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Published inBiochemistry (Moscow). Supplement. Series B, Biomedical chemistry Vol. 14; no. 4; pp. 356 - 362
Main Authors Kan, N. E., Khachatryan, Z. V., Chagovets, V. V., Starodubtseva, N. L., Amiraslanov, E. Yu, Tyutyunnik, V. L., Lomova, N. A., Frankevich, V. E.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.10.2020
Springer Nature B.V
Subjects
Amino acids
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Fetuses
Medicinal Chemistry
Metabolic pathways
Metabolism
Metabolites
Metabolomics
intrauterine growth restriction
biological network
metabolomics
metabolic pathways
amino acids
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Summary:— The analysis of metabolic pathways of amino acids during fetal intrauterine growth restriction (IUGR) was performed on the basis of the study of the metabolomic profile in pregnant women. This analysis revealed pathways, ordered according to the levels of confidence (analysis of pathways enrichment) and values of influence (topology-based pathway analysis). Connected biological networks have been identified, built using the differences in metabolites found in the IUGR group and in the control group. These networks detect influence of individual amino acids on the metabolic pathways involved in the pathogenesis of this pregnancy complication.
ISSN:1990-7508
1990-7516
DOI:10.1134/S1990750820040071