Surface functionalized nanoparticles: A boon to biomedical science

• Published in: Chemico-biological interactions Vol. 380; p. 110537
• Main Authors: Upadhyay, Kanchan, Tamrakar, Raunak Kumar, Thomas, Sabu, Kumar, Manish
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.08.2023
• Subjects: Cancer therapy; Drug delivery; Functionalization; Nano particles; Nanomedicine; Drug delivery; Functionalization; Nanomedicine; Cancer therapy; Nano particles
• ISSN: 0009-2797; 1872-7786
• DOI: 10.1016/j.cbi.2023.110537

The rapid development of nanomedicine has increased the likelihood that manufactured nanoparticles will one day come into contact with people and the environment. A variety of academic fields, including engineering and the health sciences, have taken a keen interest in the development of nanotechnology. Any significant development in nanomaterial-based applications would depend on the production of functionalized nanoparticles, which are believed to have the potential to be used in fields like pharmaceutical and biomedical sciences. The functionalization of nanoparticles with particular recognition chemical moieties does result in multifunctional nanoparticles with greater efficacy while at the same time minimising adverse effects, according to early clinical studies. This is because of traits like aggressive cellular uptake and focused localization in tumours. To advance this field of inquiry, chemical procedures must be developed that reliably attach chemical moieties to nanoparticles. The structure-function relationship of these functionalized nanoparticles has been extensively studied as a result of the discovery of several chemical processes for the synthesis of functionalized nanoparticles specifically for drug delivery, cancer therapy, diagnostics, tissue engineering, and molecular biology. Because of the growing understanding of how to functionalize nanoparticles and the continued work of innovative scientists to expand this technology, it is anticipated that functionalized nanoparticles will play an important role in the aforementioned domains. As a result, the goal of this study is to familiarise readers with nanoparticles, to explain functionalization techniques that have already been developed, and to examine potential applications for nanoparticles in the biomedical sciences. This review's information is essential for the safe and broad use of functionalized nanoparticles, particularly in the biomedical sector. •Surface functionalization of Nanoparticles.•Types and properties of nanoparticles.•Synthesis of nanoparticles.•Application of nanoparticles.