X-ray Contrast Properties of Bismuth-Based Nanoformulations

The possibility of using elemental bismuth nanoparticles as sensitizers for radiation therapy and computed tomography contrast agents is investigated. A comparative analysis of the X-ray contrast properties of bismuth nanoparticles with classical gold nanoparticles and bismuth oxychloride nanosheets...

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Published inBulletin of the Lebedev Physics Institute Vol. 50; no. Suppl 11; pp. S1265 - S1271
Main Authors Savinov, M. S., Griaznova, O. Y., Tikhonowski, G. V., Popov, A. A., Zavestovskaya, I. N., Klimentov, S. M., Kabashin, A. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.12.2023
Springer Nature B.V
Subjects
Bismuth
Computed tomography
Contrast agents
Gold
Nanoparticles
Nanostructure
Nanostructures
Physics
Physics and Astronomy
Radiation therapy
Synthesis
computed tomography
nanomedicine
nanoparticles
laser ablation in liquid
bismuth
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Summary:The possibility of using elemental bismuth nanoparticles as sensitizers for radiation therapy and computed tomography contrast agents is investigated. A comparative analysis of the X-ray contrast properties of bismuth nanoparticles with classical gold nanoparticles and bismuth oxychloride nanosheets is carried out. It is shown that laser-synthesized bismuth nanoparticles demonstrate higher X-ray contrast efficiency compared to traditional gold nanoparticles; they also have X-ray contrast properties similar to those of chemically synthesized analogues based on bismuth oxychloride nanosheets. Unique physicochemical characteristics in combination with high radiopaque properties of laser-synthesized bismuth nanoparticles form a new promising alternative to traditional sensitizers for radiation theranostics of oncological diseases.
ISSN:1068-3356
1934-838X
DOI:10.3103/S1068335623220141