Influence of Antidepressant Drug on the Conductivity of Cationic Surfactant

In this study, the electrical conductivity of the antidepressant drug—nortriptyline hydrochloride and conventional surfactant—cetyldimethylethylammoniumbromide are investigated. The experimental critical micelle concentration and related thermodynamic parameters, such as Gibbs free energy, enthalpy,...

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Bibliographic Details
Published inColloid journal of the Russian Academy of Sciences Vol. 85; no. 5; pp. 846 - 853
Main Authors Malik, N. A., Farooq, U., Malik, A., Rather, M. A.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.10.2023
Springer Nature B.V
Subjects
Antidepressants
Chemistry
Chemistry and Materials Science
Electrical resistivity
Enthalpy
Entropy
Gibbs free energy
Micelles
Polymer Sciences
Surfaces and Interfaces
Surfactants
Thin Films
antidepressant drug
conductivity
thermodynamic parameters
cationic surfactant
drug-surfactant interactions
cetyldimethylethylammoniumbromide
nortriptyline hydrochloride
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Summary:In this study, the electrical conductivity of the antidepressant drug—nortriptyline hydrochloride and conventional surfactant—cetyldimethylethylammoniumbromide are investigated. The experimental critical micelle concentration and related thermodynamic parameters, such as Gibbs free energy, enthalpy, entropy change, as well as and excess change in Gibbs free energy are calculated using standard equations. The values of change in Gibbs free energy for the mixed nortriptyline hydrochloride with cetyldimethylethylammoniumbromide are found to be more negative further suggesting the mixed micellization to be favourable. However, the high values of change in entropy are observed owing to the charge on the head groups which are being partially neutralized by the counter ions upon micelle formation.
ISSN:1061-933X
1608-3067
DOI:10.1134/S1061933X22600555