Molecular Aspects of the Geroprotective Effect of Peptide KE in Human Skin Fibroblasts

• Published in: Advances in gerontology Vol. 8; no. 3; pp. 235 - 238
• Main Authors: Fridman, N. V., Linkova, N. S., Polyakova, V. O., Drobintseva, A. O., Trofimova, S. V., Kvetnoy, I. M., Khavinson, V. Kh
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.07.2018; Springer Nature B.V
• Subjects: Aging; Antibodies; Cell culture; Collagen; Data processing; Epigenetics; Fibroblasts; Geriatrics/Gerontology; Medicine; Medicine & Public Health; Microscopy; Peptides; Senescence; Skin; Variance analysis; United States > US; peptide KE; skin fibroblasts; cellular senescence
• ISSN: 2079-0570; 2079-0589
• DOI: 10.1134/S2079057018030050

Skin aging is an current problem of modern geriatric cosmetology. One promising method to decelerate the process of age-related skin changes is the use of cosmetics with short peptides. The goal of the work was to study the effect of peptide KE (Lys-Glu, Vilon) on the expression of aging markers of human fibroblasts in an in vitro model. The expression of collagen type 1 and sirtuin 6 was studied with immunofluorescent confocal microscopy in “young” and “old” cultures of skin fibroblasts. It has been found that the area of expression of collagen type 1 and sirtuin 6 decreases by 3.5 and 3.6 times, respectively, in skin fibroblast cultures with aging. Peptide KE increases the expression area of collagen type 1 in old skin fibroblast cultures by 83%; the expression area of sirtuin 6 in young and old cultures of skin fibroblasts increased by 1.6 and 2.6 times, respectively. Thus, peptide KE increases the functional activity of skin fibroblasts and decelerates their senescence.