Risk factors for the development of vaginal intraepithelial neoplasia

• Published in: Chinese medical journal Vol. 125; no. 7; pp. 1219 - 1223
• Main Authors: Li, Hua, Guo, Yan-li, Zhang, Jing-xu, Qiao, Jie, Geng, Li
• Format: Journal Article
• Language: English
• Published: China Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China%Division of Maternal and Child Health, School of Public Health,Peking University, Beijing 100191, China 01.04.2012
• Subjects: Adult; Carcinoma in Situ - complications; Case-Control Studies; Cervical Intraepithelial Neoplasia - complications; Female; Humans; Middle Aged; Papillomavirus Infections - complications; Risk Factors; Uterine Cervical Neoplasms - complications; Vaginal Neoplasms - epidemiology; Vaginal Neoplasms - etiology; 中国人口; 乳头状瘤病毒; 危险因素; 历史资料; 多元统计分析; 子宫颈癌; 病变; 阴道上皮; vaginal intraepithelial neoplasia; risk factor; cervical intraepithelial neoplasia; human papillomavirus
• ISSN: 0366-6999; 2542-5641; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.2012.07.006

Background Vaginal intraepithelial neoplasia （VAIN）, as a precursor of vaginal cancer, is a rare disease. Its prevalence has not been well analyzed. This research is to ascertain the risk factors for VAIN in a Chinese population. Methods A case-control study was conducted, including 63 VAIN cases and 64healthy controls. In all subjects Pap smear and HPV tests were performed. A questionnaire survey was distributed, covering information on socio-demographic characteristics, smoking, past history, reproductive and sexual histories. The clinical pathological data were collected from medical records including symptoms, Pap smear results, grade of lesions, and human papillomavirus （HPV） status. Results Postmenopausal women had a 2.09 times higher risk for VAIN than pre-menopausal women （95% CI： 1.10-3.85; P=-0.024）. The patients with previous hysterectomy had an increased risk of VAIN （OR=4.69; P=0.003）. Patients with a history of cervical cancer or CIN were predisposed to VAIN （OR=78.75; P 〈0.0001）. The rate of HPV infection in VAIN was significantly higher than in controls, and an increased risk of VAIN was observed in patients with higher viral load （OR=126.00; P=0.000）. Multivariate analysis showed that HPV infection and a history of CIN or cervical cancer were still found to be significant in patients. Conclusion HPV infection and a history of CIN or cervical cancer are the main risk factors for the development of VAIN.