Catalytic asymmetric nucleophilic openings of 3-substituted oxetanes

Asymmetric ring-opening of 3-substituted oxetanes provides rapid access to highly functionalized chiral building blocks. However, progress in this field is limited. Recently we developed a new catalytic system based on chiral Brønsted acids for this type of reaction and demonstrated the synthesis of...

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Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 12; no. 32; pp. 6028 - 6032
Main Authors Wang, Zhaobin, Chen, Zhilong, Sun, Jianwei
Format Journal Article
LanguageEnglish
Published England 28.08.2014
Subjects
Catalysis
Cobalt - chemistry
Ethers, Cyclic - chemistry
Isoquinolines - chemistry
Models, Molecular
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Summary:Asymmetric ring-opening of 3-substituted oxetanes provides rapid access to highly functionalized chiral building blocks. However, progress in this field is limited. Recently we developed a new catalytic system based on chiral Brønsted acids for this type of reaction and demonstrated the synthesis of a range of useful molecules under mild and operationally simple conditions. In this perspective, we describe the challenges, progress, and potential future efforts on this topic.
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SourceType-Scholarly Journals-1
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ISSN:1477-0520
1477-0539
DOI:10.1039/c4ob00920g