Synthesis of 7-chloro-4-substituted aminoquinolines and their in vitro ability to produce methemoglobin in canine hemolysate

Synthesis of aminoquinoline derivatives (2–15) and their in vitro effects on methemoglobin formation and methemoglobin reductase activity are delineated. Some of the screened compounds have shown considerable methemoglobin toxicity. Synthesis of aminoquinoline derivatives ( 2–15) and their in vitro...

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Published inBioorganic & medicinal chemistry letters Vol. 7; no. 21; pp. 2741 - 2746
Main Authors Srivastava, Sandhya, Tewari, Swati, Srivastava, Sanjay K., Chauhan, P.M.S., Bhaduri, A.P., Puri, S.K., Pandey, V.C.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 04.11.1997
Elsevier
Subjects
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Medical sciences
Pharmacology. Drug treatments
Toxicity: blood
Fissipedia
Hemoglobinopathy
Antimalarial
Carnivora
Enzyme
Nitrogen heterocycle
Toxicity
Hemopathy
Methemoglobin
In vitro
Blood
reductase
Vertebrata
Mammalia
Enzymatic activity
Structure activity relation
Chlorine Organic compounds
Animal
Parasiticid
Bicyclic compound
Aromatic compound
Oxidoreductases
Dog
Cytochrome-b
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Summary:Synthesis of aminoquinoline derivatives (2–15) and their in vitro effects on methemoglobin formation and methemoglobin reductase activity are delineated. Some of the screened compounds have shown considerable methemoglobin toxicity. Synthesis of aminoquinoline derivatives ( 2–15) and their in vitro effects on methemoglobin formation and methemoglobin reductase activity are delineated. Some of the screened compounds have shown considerable methemoglobin toxicity.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(97)10074-9