Synthesis and Docking Study of Novel Pyranocoumarin Derivatives

A new series of fused tricyclic coumarin derivatives were designed, synthesized by a simple and convenient method, starting from 4-hydroxycoumarin and virtually screened by molecular docking on the target protein 3FRZ (PDB ID: 3FRZ), a HCV RNA-dependent RNA polymerase, for potency against hepatitis...

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Bibliographic Details
Published inRussian journal of organic chemistry Vol. 57; no. 2; pp. 272 - 282
Main Authors Karteek, S. Durga, Reddy, A. Gopi, Tej, M. Bhuvan, Rao, M. V. Basaveswara
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.02.2021
Springer Nature
Springer Nature B.V
Subjects
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Coumarin
Hepatitis C
Molecular docking
Organic Chemistry
Physical Sciences
Proteins
RNA polymerase
Science & Technology
Synthesis
4-hydroxycoumarin
docking studies
HCV
pyranocoumarins
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Summary:A new series of fused tricyclic coumarin derivatives were designed, synthesized by a simple and convenient method, starting from 4-hydroxycoumarin and virtually screened by molecular docking on the target protein 3FRZ (PDB ID: 3FRZ), a HCV RNA-dependent RNA polymerase, for potency against hepatitis C virus (HCV). Efficient binding to the target protein was found for most of the synthesized compounds.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428021020196