Value of percutanous catheter fragmentation in the management of massive pulmonary embolism

• Published in: Chinese medical journal Vol. 122; no. 15; pp. 1723 - 1727
• Main Authors: Zhou, Wei-zhong, Shi, Hai-bin, Yang, Zheng-qiang, Liu, Sheng, Zhou, Chun-gao, Zhao, Lin-bo, Xia, Jin-guo, Feng, Yao-liang, Li, Lin-sun
• Format: Journal Article
• Language: English
• Published: China Department of Interventional Radiology,First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China 05.08.2009
• Subjects: Adult; Aged; Aged, 80 and over; Catheterization - methods; Female; Humans; Male; Middle Aged; Pulmonary Embolism - diagnostic imaging; Pulmonary Embolism - therapy; Retrospective Studies; Thrombolytic Therapy - methods; Tomography, X-Ray Computed; Vena Cava Filters; Young Adult; 临床治疗; 临床疗效; 价值; 导管; 栓塞; 管理; 肺动脉; 面积; thrombolysis; pulmonary embolism; catheter fragmentation
• ISSN: 0366-6999; 2542-5641; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.2009.15.001

Background Acute massive pulmonary embolism （PE） is a clinical emergency requiring rapid and supportive measures. Percutanous mechanical thrombectomy is considered as a treatment option. The purpose of this study was to evaluate the clinical efficacy and safety of peructaneous mechanical catheter fragmentation in the management of acute massive PE. Methods From January 2003 to June 2007, 28 patients （20 men, 8 women; mean age 64 years） with acute massive PE initially diagnosed by computed tomography and confirmed by pulmonary angiography were treated with inferior vena caval filter placement and percutaneous catheter fragmentation. Twenty-six patients received thrombolytic agents after embolus fragmentation. Results Technical success was achieved in all patients. The improvement of clinical status and restoration of blood flow in the main branches of the pulmonary artery were seen in 27 patients. Only one case did not benefit from the percutaneous therapy and died from the failure of the surgery. Oxygen saturation increased from （86.2±4.5）% to （96.1±3.2）% （P 〈0.001） after the interventional procedure. The post-procedure mean pulmonary artery pressure decreased from （34.2±4.8） mmHg to （25.2±5.1） mmHg （P 〈0.001）. During clinical follow-up （range, 1-5 years）, no patients had recurrence of PE. Conclusion Percutaneous catheter fragmentation combined with thrombolysis is an effective and safe therapy in the clinical management of acute massive PE.