Diagnostic performance of magnetic resonance venography in the detection of recanalization in patients with chronic cerebral venous sinus thrombus

• Published in: Chinese medical journal Vol. 122; no. 20; pp. 2428 - 2432
• Main Authors: Sun, Ying, Zheng, Dong-you, Ji, Xun-ming, Weale, Peter, Wu, Hao, Jiang, Li-dan, Yang, Li-zhuang
• Format: Journal Article
• Language: English
• Published: China Department of Neurosurgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150086, China%Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 1000950, China%Department of Neurosurgery,Xuanwu Hospital, Capital Medical University, Beijing 100053, China%Siemens Medical Solutions USA, Inc., Chicago, IL 60611, USA%Department of Radiology,Xuanwu Hospital, Capital Medical University, Beijing 100053, China 20.10.2009
• Subjects: Adolescent; Adult; Aged; Child; Female; Humans; Magnetic Resonance Angiography - methods; Male; Middle Aged; Prospective Studies; Reproducibility of Results; Sinus Thrombosis, Intracranial - diagnosis; Sinus Thrombosis, Intracranial - pathology; Young Adult; 数字减影血管造影; 磁共振; 血栓形成; 静脉窦; digital subtraction; cranial; magnetic resonance venography; venous sinus thrombosis; angiography
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.2009.20.006

Background In the chronic stage of cerebral venous sinus thrombosis （CVST）, recanalization can result in disparate MR appearances. We aimed to prospectively investigate the diagnostic accuracy of magnetic resonance venography （MRV） in the evaluation of the recanalization of CVST. Methods This study prospectively evaluated the diagnostic performance of 2-dimensional time-of-flight （2D-TOF） MRV in thirty-two consecutive patients during a threeto six-month follow-up for CVST. Both 2D-TOF MRV and digital substraction angiography （DSA） were undertaken. Diagnostic accuracy of 2D-TOF MRV in the detection of recanalized thrombus was evaluated using DSA as the reference standard. Results MRV and DSA were completed without complications in all 32 patients. The sensitivity, specificity, positive predictive value, and negative predictive value of 2D-TOF MRV for the detection of recanalization on a segmental basis were 91% （62/68）, 93% （37/40）, 95% （62/65）, and 86% （37/43） respectively. Conclusion 2D-TOF MRV provides high sensitivity and specificity for the diagnosis of recanalized CVST segments.