OX40 mRNA in peripheral blood as a biomarker of acute renal allograft rejection

Background Acute rejection remains an important cause of renal allograft dysfunction and the need for accurate diagnosis is essential to successfully treat transplant recipients. The purpose of this study was to determine the costimulatory molecules OX40 and OX40L messenger RNA （mRNA） levels in peri...

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Published inChinese medical journal Vol. 125; no. 21; pp. 3786 - 3790
Main Authors Wang, Yu-Liang, Fu, Ying-Xin, Zhu, Zhi-Jun, Wang, Hui, Shen, Zhong-Yang
Format Journal Article
LanguageEnglish
Published China Department of Transplantation Surgery, Tianjin First Central Hospital, Key Laboratory for Critical Care Medicine of the Ministry of Health, Tianjin 300192, China 05.11.2012
Subjects
Adult
Biomarkers - blood
Female
Graft Rejection - blood
Graft Rejection - diagnosis
Humans
Kidney Transplantation - adverse effects
Male
Middle Aged
mRNA
OX40 Ligand - genetics
Receptors, OX40 - genetics
RNA, Messenger - blood
ROC Curve
Transplantation, Homologous
信使RNA
外周血单个核细胞
急性
排斥反应
生物标志物
肾功能不全
肾移植
OX40
costimulation
acute rejection
renal transplantation
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Summary:Background Acute rejection remains an important cause of renal allograft dysfunction and the need for accurate diagnosis is essential to successfully treat transplant recipients. The purpose of this study was to determine the costimulatory molecules OX40 and OX40L messenger RNA （mRNA） levels in peripheral blood mononuclear cells （PBMCs） to predict acute renal transplant rejection.
Bibliography:OX40; costimulation; acute reiection; renal transplantation
Background Acute rejection remains an important cause of renal allograft dysfunction and the need for accurate diagnosis is essential to successfully treat transplant recipients. The purpose of this study was to determine the costimulatory molecules OX40 and OX40L messenger RNA （mRNA） levels in peripheral blood mononuclear cells （PBMCs） to predict acute renal transplant rejection.
11-2154/R
WANG Yu-liang, FU Ying-xin, ZHU Zhi-jun, WANG Hui and SHEN Zhong-yang Department of Transplantation Surgery, Tianjin First Central Hospital, Key Laboratory for Critical Care Medicine of＂ the Ministry of Health, Tianjin 300192,China
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0366-6999
2542-5641
2542-5641
DOI:10.3760/cma.j.issn.0366-6999.2012.21.007