Analgesic effect of parecoxib and flurbiprofen axetil for patients undergoing laparoscopic cholecystectomy and their influences on platelet aggregation

• Published in: Chinese medical journal Vol. 123; no. 12; pp. 1607 - 1609
• Main Authors: Ji, Fu-hai, Jin, Xin, Yang, Jian-ping, Zan, Li-li
• Format: Journal Article
• Language: English
• Published: China Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China%Department of Anesthesiology, Suzhou Municipal Hospital,Suzhou, Jiangsu 215008, China 20.06.2010
• Subjects: Analgesia - methods; Cholecystectomy, Laparoscopic - methods; Female; Flurbiprofen - analogs & derivatives; Flurbiprofen - pharmacology; Humans; Isoxazoles - pharmacology; Male; Platelet Aggregation - drug effects; 临床应用; 切除术; 皮肤瘙痒; 腹腔镜; 血小板聚集; 镇痛作用; 非甾体抗炎药; parecoxib; fiurbiprofen axetil; cyclooxygenase inhibitor; analgesia
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.2010.12.023

It is known that opioids produce postoperative analgesia, while it can also cause, especially in large doses, side effects like nausea, vomiting, constipation, syncope, skin itching, urinary retention and even respiratory inhibition. These factors have all greatly limited its clinical use for treating postoperative pain. Meanwhile, non-steroidal anti-inflammatory drugs （NSAIDs） play an increasingly important role in postoperative analgesia. Some studies suggest that NSAIDS may be neural protective in cerebral ischemic conditions.