Ni-Catalyzed Reductive Coupling of Alkyl Carbonochloridates and Aryl Iodides

A Ni-catalyzed reductive coupling of alkyl carbonochloridates and aryl iodides for the synthesis of aromatic esters has been developed. The present method is a new type of reductive coupling for building Csp2-CO bonds, and it avoids using toxic carbon monoxide gas. It tolerates various aryl iodides,...

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Bibliographic Details
Published inSynlett Vol. 34; no. 17; pp. 2001 - 2004
Main Authors Liu, Chonghuo, Yao, Ken, Chen, Yunrong
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 24.10.2023
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
OXIDATIVE CARBONYLATION
HALIDES
REAGENTS
alkyl carbonochloridate
ACIDS
reductive coupling
KETONE FORMATION
Ni catalysis
aryl ester
BROMIDES
BENZYL
ESTERS
CARBOXYLATION
Csp -Csp coupling
ASTERISK-CARBONYLIERUNG
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Summary:A Ni-catalyzed reductive coupling of alkyl carbonochloridates and aryl iodides for the synthesis of aromatic esters has been developed. The present method is a new type of reductive coupling for building Csp2-CO bonds, and it avoids using toxic carbon monoxide gas. It tolerates various aryl iodides, and a coordinating group in alkyl carbonochloridates is key to improving the yield of the reaction.
ISSN:0936-5214
1437-2096
DOI:10.1055/a-2131-3157