Possible Role of Prep1 Homeodomain Transcription Factor in Cardiac Mesenchymal Stromal Cells

—Homeodomain transcription factors play a significant role in mesenchymal stromal cells (MSCs). Previously, the role of Meis1, Pbx1 and Prep1 proteins from the TALE (Three Amino acid Loop Extension) family in adipocytic and osteogenic differentiation of mouse mesenchymal stromal cells was establishe...

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Bibliographic Details
Published inMolecular biology (New York) Vol. 55; no. 6; pp. 847 - 853
Main Authors Stafeev, Y. S., Shevchenko, E. K., Boldireva, M. A., Penkov, D. N.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.11.2021
Springer Nature B.V
Subjects
Amino acids
Biochemistry
Biomedical and Life Sciences
Cardiomyocytes
Cell differentiation
Fibroblasts
Genomics. Transcryptomics
Heart
Homeobox
Human Genetics
Life Sciences
Mesenchymal stem cells
Mesenchyme
Stromal cells
Transcription factors
transcription factor
PREP1
cardiomyocyte
mesenchymal stromal cells
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Summary:—Homeodomain transcription factors play a significant role in mesenchymal stromal cells (MSCs). Previously, the role of Meis1, Pbx1 and Prep1 proteins from the TALE (Three Amino acid Loop Extension) family in adipocytic and osteogenic differentiation of mouse mesenchymal stromal cells was established. In this work, using ChIP-seq and bioinformatic analysis we investigated the binding pattern of PREP1 with the genomic DNA of human heart MSCs, identified nearby genes, and analyzed their ontology. The target genes of the PREP1 factor in cardiac MSCs have been established. Based on the results, the possible involvement of transcription factor PREP1 in the direct reprogramming of fibroblasts into cardiomyocytes is discussed.
ISSN:0026-8933
1608-3245
DOI:10.1134/S0026893321050125