Synthesis of Aryl Dithiocarbamates from Tetramethylthiuram Monosulfide (TMTM) and Aryl Boronic Acids: Copper-Catalyzed Construction of C(sp2)-S Bonds

A highly efficient method for the synthesis of S-aryl dithiocarbamates is reported. By using tetramethylthiuram monosulfide (TMTM) and aryl boronic acids as starting materials, C(sp(2))-S bond-forming reactions proceed smoothly to give the desired aryl dithiocarbamates in good to excellent yields. T...

Full description

Saved in:
Bibliographic Details
Published inSynthesis (Stuttgart) Vol. 54; no. 2; pp. 475 - 482
Main Authors Xia, Xu-Ling, Zhu, Qi-Long, Chen, Jin-Quan, Shi, Zhen, Dong, Zhi-Bing
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 18.01.2022
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
tetramethylthiuram monosulfide
SULFIDES
ONE-POT
THIOLATION
EFFICIENT SYNTHESIS
THIOAMIDES
TETRAALKYLTHIURAM DISULFIDES
dithiocarbamates
IODIDES
CROSS-COUPLING REACTIONS
S-ARYLATION
organosulfur
copper
DERIVATIVES
boronic acids
Online AccessGet more information
ISSN0039-7881
1437-210X
DOI10.1055/a-1645-6040

Cover

More Information
Summary:A highly efficient method for the synthesis of S-aryl dithiocarbamates is reported. By using tetramethylthiuram monosulfide (TMTM) and aryl boronic acids as starting materials, C(sp(2))-S bond-forming reactions proceed smoothly to give the desired aryl dithiocarbamates in good to excellent yields. The methodology features a simple procedure, broad functional group tolerance and excellent yields, whilst showing potential synthetic value for the preparation of a diverse range of biologically and pharmaceutically active compounds.
ISSN:0039-7881
1437-210X
DOI:10.1055/a-1645-6040