Cobaltocenium acetylsalicylate: synthesis and circular dichroism study of interactions with DNA

Cobaltocenium acetylsalicylate was synthesized and characterized for the first time. The concentration dependences observed in its interaction with the double helix of DNA have been studied by circular dichroism. In these spectra, changes in the positions and decrease in the intensities of the curve...

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Bibliographic Details
Published inRussian chemical bulletin Vol. 68; no. 9; pp. 1787 - 1790
Main Authors Snegur, L. V., Kaverin, M. V., Babievsky, K. K.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.09.2019
Springer Nature B.V
Subjects
Brief Communications
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Deoxyribonucleic acid
Dichroism
DNA
Inorganic Chemistry
Organic Chemistry
Cotton effect
circular dichroism
DNA
cobaltocenium salt
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Summary:Cobaltocenium acetylsalicylate was synthesized and characterized for the first time. The concentration dependences observed in its interaction with the double helix of DNA have been studied by circular dichroism. In these spectra, changes in the positions and decrease in the intensities of the curves in the positive and negative regions are observed when adding in increasing concentrations of cobaltocenium acetylsalicylate to calf thymus DNA. The observed changes in the effects of Cotton were interpreted as local changes in the conformation of the DNA double helix caused by the interaction of positively charged metallocenium cations with phosphate DNA fragments.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-019-2625-x