Outcomes following debridement, antibiotics and implant retention in the management of periprosthetic infections of the hip: a review of cohort studies

• Published in: The bone & joint journal Vol. 99-B; no. 11; pp. 1458 - 1466
• Main Authors: Tsang, S-T J, Ting, J, Simpson, A H R W, Gaston, P
• Format: Journal Article
• Language: English
• Published: England 01.11.2017
• Subjects: Anti-Bacterial Agents - therapeutic use; Arthroplasty, Replacement, Hip - instrumentation; Combined Modality Therapy; Debridement; Hip Prosthesis - adverse effects; Humans; Prosthesis-Related Infections - therapy; Time Factors; Treatment Outcome; Implant retention; Infection; Debridement; Arthroplasty; Revision arthroplasty
• ISSN: 2049-4394; 2049-4408
• DOI: 10.1302/0301-620X.99B11.BJJ-2017-0088.R1

The aims of the study were to review and analyse the reported series of debridement, antibiotics and implant retention (DAIR) in the management of infected total hip arthroplasties (THAs) to establish the overall success and the influencing factors. Using a standardised recognised study protocol, meta-analysis of observational studies in epidemiology guidelines, a comprehensive review and analysis of the literature was performed. The primary outcome measure was the success of treatment. The search strategy and inclusion criteria which involved an assessment of quality yielded 39 articles for analysis, which included 1296 patients. The proportion of success following DAIR in the management of an infected THA appeared to improve after 2004 with a pooled mean proportion of success of 72.2%. For all reported series, from 1977 onwards, there was improved success with early debridement (< 7 days; 75.7%) and exchange of modular components (77.5%). There was a statistically non-significant improvement if debridement was performed within four weeks of the initial procedure (73.0%). The reported success following DAIR has improved since 2004. The only determinants of outcome which we found were the timing of debridement after the onset of symptoms of infection and the exchange of modular components. Cite this article: Bone Joint J 2017;99-B:1488-66.