Inflammatory response of uric acid produced by Porphyromonas gingivalis gingipains

Uric acid is a potential metabolite that serves as a danger‐associated molecular pattern (DAMP) and induces inflammatory responses in sterile environments. Porphyromonas gingivalis is a keystone periodontopathogen, and its gingipain proteases play a critical role in the pathogenesis of periodontitis...

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Published inMolecular oral microbiology Vol. 35; no. 5; pp. 222 - 230
Main Authors Jun, Hye‐Kyung, An, Sun‐Jin, Kim, Hyun Young, Choi, Bong‐Kyu
Format Journal Article
LanguageEnglish
Published Denmark Wiley Subscription Services, Inc 01.10.2020
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Summary:Uric acid is a potential metabolite that serves as a danger‐associated molecular pattern (DAMP) and induces inflammatory responses in sterile environments. Porphyromonas gingivalis is a keystone periodontopathogen, and its gingipain proteases play a critical role in the pathogenesis of periodontitis. In this study, we demonstrate that P. gingivalis gingipains play a role in THP‐1 macrophage uric acid production by increasing the expression and activity of xanthine oxidoreductase (XOR). Uric acid sodium salt induces caspase‐1 activation, cell death, and the expression of proinflammatory cytokines, including IL‐1α, IL‐6, and IL‐8, in the human keratinocyte HOK‐16B cell line. Our results suggest that gingipain‐induced uric acid can mediate inflammation in periodontal tissue cells. The blurb content for the graphical abstrct is P. gingivalis gingipains induce uric acid production in THP‐1 macrophages by increasing the expression and activity of xanthine oxidoreductase. Uric acid sodium salt induces caspase‐1 activation, cell death, and the expression of proinflammatory cytokines in the human keratinocyte HOK‐16B cells.
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ISSN:2041-1006
2041-1014
DOI:10.1111/omi.12309