Combinatorial effect of nicotine and black tea on heart rate variability: Useful or harmful?

• Published in: Autonomic & autacoid pharmacology Vol. 37; no. 3; pp. 44 - 48
• Main Authors: Joukar, S., Sheibani, M.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.06.2017
• Subjects: Animals; Autonomic nervous system; Autonomic Nervous System - drug effects; black tea; Cardiac arrhythmia; Electrocardiography - methods; Heart - drug effects; Heart rate; Heart Rate - drug effects; HRV; Male; Nicotine; Nicotine - pharmacology; Rats; Rats, Wistar; Rodents; Tea; Tea - chemistry; Vagus nerve; Vagus Nerve - drug effects; nicotine; autonomic nervous system; HRV; black tea
• ISSN: 1474-8665; 1474-8673
• DOI: 10.1111/aap.12059

Summary The effect of nicotine on heart rate variability (HRV) is controversial. Autonomic nervous system is the main regulator of heart rhythm, and heart rate variability is an appropriate index to assessment of the effects of the autonomic system on heart. In this study, the combination effect of nicotine and black tea consumption on sympatho‐vagal balance and heart rate variability was investigated in rats. Male Wistar rats were randomized into four groups as control, tea (2.5 g/100 cc, daily), nicotine (2 mg/kg/d) and tea plus nicotine groups which treated for 28 days, and in the 29th day, their electrocardiograms (lead II) were recorded. The mean of high‐frequency power (HF) in tea, nicotine and tea plus nicotine groups was significantly more than control group (P < .05), and low‐frequency power/high‐frequency power (LF/HF) ratio in the nicotine and tea + nicotine groups was significantly less than control group (P < .05). LF values did not differ significantly among groups. Mean of standard deviation of normal RR intervals (SDNN) and square root of the mean squared differences of successive RR intervals (RMSSD) increased significantly in tea, nicotine and tea + nicotine groups in comparison with control group (P < .05) Overall, 4‐week administration of black tea, nicotine or their combination with dosages used in this study can increase the heart rate variability and improve the sympatho‐vagal balance in rat.