The Influence of Simple Phenols on Collagen Type I Fibrillogenesis in vitro

The influence of phenolic compounds with different numbers of hydroxy groups (phenol, pyrocatechol, resorcinol, and pyrogallol) on the kinetics of in vitro fibrillogenesis of collagen and on fibril structure has been studied. It has been shown that these phenols accelerate fibril formation mainly by...

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Published inBiophysics (Oxford) Vol. 63; no. 2; pp. 162 - 168
Main Authors Kim, Yu. A., Gaidin, S. G., Tarahovsky, Yu. S.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.03.2018
Springer Nature B.V
Subjects
Biological and Medical Physics
Biophysics
Catechol
Collagen
Collagen (type I)
Fibrillogenesis
Hydrogen bonding
Hydrogen bonds
Intermediates
Lag phase
Molecular Biophysics
Phenolic compounds
Phenols
Physics
Physics and Astronomy
Pyrogallol
Resorcinol
phenol
resorcinol
type I collagen
fibrillogenesis
pyrocatechol
pyrogallol
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Summary:The influence of phenolic compounds with different numbers of hydroxy groups (phenol, pyrocatechol, resorcinol, and pyrogallol) on the kinetics of in vitro fibrillogenesis of collagen and on fibril structure has been studied. It has been shown that these phenols accelerate fibril formation mainly by shortening the lag phase, presumably facilitating the formation of collagen dimers and their subsequent association to linear aggregates. The accelerating activity of phenols is proportional to the number of hydroxy groups in the molecule. It increases in the series: phenol < resorcinol < pyrogallol. Therefore, the ability of phenols to accelerate fibril formation is likely to stem from the formation of hydrogen bonds with amino-acid residues in collagen chains. The hydrogen bonds may stabilize the structure of the intermediates, facilitating their interaction during fibrillogenesis.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350918020148