Dynamic Hydrostatic Loading Experiments for Nerve Cells and Development of Damage Evaluation Technique

In this paper, a new head injury criterion evaluated by the hydrostatic stress occurred in the head crash phenomenon. In order to obtain the threshold value for brain's organ and tissue, in vitro impact experiments to cultured nerve cells were performed. PC-12 cultured nerve cell was employed t...

Full description

Saved in:
Bibliographic Details
Published inTransactions of the Japan Society of Mechanical Engineers Series A Vol. 71; no. 701; pp. 73 - 79
Main Authors NAKAMACHI, Eiji, MIKI, Kazuo, FURUKAWA, Kazunori, TAKEGAWA, Yuichi, DOI, Teppei
Format Journal Article
LanguageJapanese
Published The Japan Society of Mechanical Engineers 2005
Subjects
Crash
Cultured Nerve Cell
Damage Evaluation
Hydrostatic Pressure
Injury Criterion
Online AccessGet full text

Cover

More Information
Summary:In this paper, a new head injury criterion evaluated by the hydrostatic stress occurred in the head crash phenomenon. In order to obtain the threshold value for brain's organ and tissue, in vitro impact experiments to cultured nerve cells were performed. PC-12 cultured nerve cell was employed to imitate the human's nerve cell. In the experiments, various pressure waves were generated by introducing different heights of dropping weight for impacting. Relationships between peak values of impact compressive and expansive pressure waves and detachment rates and injury rates evaluated by the cell membranes damage were obtained.
ISSN:0387-5008
1884-8338
DOI:10.1299/kikaia.71.73