Cancer risk‐reducing surgery: Brazilian society of surgical oncology guideline part 1 (gynecology and breast)

• Published in: Journal of surgical oncology Vol. 126; no. 1; pp. 10 - 19
• Main Authors: Carneiro, Vandré Cabral Gomes, Gifoni, Ana Carolina Leite Vieira Costa, Mauro Rossi, Benedito, Andrade, Carlos Eduardo Mattos da Cunha, Lima, Fernanda Teresa de, Galvão, Henrique de Campos Reis, Casali da Rocha, Jose Claudio, Silva Barreto, Leonardo Silveira da, Ashton‐Prolla, Patrícia, Guindalini, Rodrigo Santa Cruz, Farias, Terence Pires de, Andrade, Wesley Pereira, Fernandes, Paulo Henrique de Sousa, Ribeiro, Reitan, Lopes, Andre, Tsunoda, Audrey Tieko, Azevedo, Bruno Roberto Braga, Marins, Carlos Augusto Martinez, Oliveira Uchôa, Diego Nunes de Albuquerque, Dos Santos, Evandro Airton Sordi, Fernández Coimbra, Felipe José, Dias Filho, Francisco Alcides, Lopes, Francisco Carlos de Oliveira, Fernandes, Francisco Guilherme, Ritt, Guilherme Fonteles, Laporte, Gustavo Andreazza, Guimaraes, Gustavo Cardoso, Feitosa e Castro Neto, Heládio, Santos, Jocela Cristina, Carvalho Vilela, Jordana Botelho, Meinhardt Junior, Jorge Guardiola, Cunha, Juliano Rodrigues da, Medeiros Milhomem, Leonardo, Silva, Luciana Mata, Maciel, Luiza de Freitas, Ramalho, Nathalia Moreira, Leite Nunes, Rafael, Guido de Araújo, Rodrigo, Assunção Ehrhardt, Rogério, Delgado Bocanegra, Ronald Enrique, Silva Junior, Tyrone Cesar, Oliveira, Viviane Rezende de, Silva Surimã, Walyson, Melo Melquiades, Miriam, Ribeiro, Heber Salvador de Castro, Oliveira, Alexandre Ferreira
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2022
• Subjects: Brazil - epidemiology; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - prevention & control; Breast Neoplasms - surgery; Cancer; cancer risk‐reducing; Female; Gynecology; Humans; Mastectomy; Ovarian cancer; Ovarian Neoplasms - surgery; practice guideline; surgery; Surgical Oncology; Brazil; breast cancer; cancer risk-reducing; ovarian cancer; practice guideline; surgery
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/jso.26812

Background Risk‐reducing operations are an important part of the management of hereditary predisposition to cancer. In selected cases, they can considerably reduce the morbidity and mortality associated with cancer in this population. Objectives The Brazilian Society of Surgical Oncology (BSSO) developed this guideline to establish national benchmarks for cancer risk‐reducing operations. Methods The guideline was prepared from May to December 2021 by a multidisciplinary team of experts to discuss the surgical management of cancer predisposition syndromes. Fourteen questions were defined and assigned to expert groups that reviewed the literature and drafted preliminary recommendations. Following a review by the coordinators and a second review by all participants, the groups made final adjustments, classified the level of evidence, and voted on the recommendations. Results For all questions including risk‐reduction bilateral salpingo‐oophorectomy, hysterectomy, and mastectomy, major agreement was achieved by the participants, always using accessible alternatives. Conclusion This and its accompanying article represent the first guideline in cancer risk reduction surgery developed by the BSSO, and it should serve as an important reference for the management of families with cancer predisposition.