Serum Calcium Level is Associated with Brachial-ankle Pulse Wave Velocity in Middle-aged and Elderly Chinese

• Published in: Biomedical and environmental sciences Vol. 27; no. 8; pp. 594 - 600
• Main Authors: Deng, Xin Ru, Zhang, Yin Fei, Wang, Tian Ge, Xu, Bai Hui, Sun, Ji Chao, Zhao, Lie Bin, Xu, Min, Chen, Yu Hong, Wang, Wei Qing, Bi, Yu Fang, Lu, Jie Li
• Format: Journal Article
• Language: English
• Published: China Key Laboratory for Endocrine and Metabolic Diseases, Ministry of Health, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, E-Institute of Shanghai Universities, Shanghai 200025, China%Department of Endocrinology and Metabolism, Central Hospital of Jiading District, Shanghai 201800, China%Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China 01.08.2014
• Subjects: Adult; Aged; Ankle Brachial Index; Asian Continental Ancestry Group; Calcium - blood; Female; Humans; Logistic回归分析; Male; Middle Aged; Pulse Wave Analysis; Vascular Stiffness - physiology; 中国; 中年; 波速度; 老年; 脉搏; 血清; 钙水平; Calcium; Brachial-ankle pulse wave velocity; Vascular stiffness
• ISSN: 0895-3988; 2214-0190
• DOI: 10.3967/bes2014.091

Objective To study the relation between serum calcium level and elevated BaPWV in Chinese subjects. Methods The relation between serum calcium level and elevated BaPWV was studied in 9 615 subjects. The mean value of left and right BaPWV was analyzed. BaPWV was defined as high when it was31 752.5 cm/s （the upper quartile） either side. Results The BaPWV and its elevated percentage progressively increased across the quartiles of the serum calcium level （P〈0.05）. The prevalence of elevated BaPWV was significantly higher in subjects of the second, third and highest quartiles than in those of the lowest quartile （26.9%, 28.4%, and 33.2%vs 23.7%, P=0.0116, P=0.0004, and P〈0.0001）. Logistic regression analysis revealed that the risk of elevated BaPWV was 1.32- fold higher in subjects of the highest quartile than in those of the lowest quartile （OR=1.32, 95%CI：1.08-1.60）. Conclusion The elevated serum calcium level is related to an elevated BaPWV and a higher risk of arterial stiffness, independent of conventional risk factors, in middle-aged and elderly Chinese subjects.