Reassessment of the predictive role of perivesical fat invasion in invasive bladder cancer prognosis in 151 Chinese patients

• Published in: Chinese medical journal Vol. 124; no. 18; pp. 2915 - 2919
• Main Authors: Zhang, Zhi-Ling, Xiong, Yong-Hong, Li, Yong-Hong, Hou, Guo-Liang, Liu, Zhuo-Wei, Han, Hui, Qin, Zi-Ke, Yun, Jing-Ping, Zhou, Fang-Jian
• Format: Journal Article
• Language: English
• Published: China Department of Urology, Cancer Center, Sun Yat-sen University, State Key Laboratory of Oncology in Southern China,Guangzhou, Guangdong 510060, China%Department of Ultrasound, Cancer Center, Sun Yat-sen University, State Key Laboratory of Oncology in Southern China,Guangzhou, Guangdong 510060, China, Cancer Center, Sun Yat-sen University, State Key Laboratory of Oncology in Southern China,Guangzhou, Guangdong 510060, China%Department of Pathology, Cancer Center, Sun Yat-sen University, State Key Laboratory of Oncology in Southern China,Guangzhou, Guangdong 510060, China 01.09.2011
• Subjects: Adult; Aged; Cystectomy; Female; Humans; Intra-Abdominal Fat - pathology; Male; Middle Aged; Multivariate Analysis; Neoplasm Invasiveness - pathology; Neoplasm Staging; Retrospective Studies; Survival Rate; Treatment Outcome; Urinary Bladder Neoplasms - mortality; Urinary Bladder Neoplasms - pathology; Urinary Bladder Neoplasms - surgery; 中国; 单因素分析; 浸润性; 肿瘤患者; 脂肪; 膀胱癌; 预后; 预测值; perivesical fat; prognosis; bladder cancer
• ISSN: 0366-6999; 2542-5641; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.2011.18.022

Background Perivesical fat invasion is considered as an important prognostic factor for bladder cancer. However, the predictive role of perivesical fat invasion in invasive bladder cancer prognosis has never been reported in Chinese patients. The aim of the study was to assess the predictive value of perivesical fat invasion for prognoses of T2 and T3 bladder cancer in Chinese patients. Methods One hundred and fifty-one patients who underwent radical cystectomy for pT2-3NOM0 invasive bladder cancer from 2001 to 2007 were studied. Cancer-specific survival rate （CSS） and recurrence-free survival rate （RFS） were compared between the pT2 and pT3 patient groups. Other clinicopathological parameters were also retrospectively analyzed by univariate and multivariate analyses to identify the independent predictor for the prognoses of this cohort. Results Average patient age at surgery was 58 years. Ninety （60.3%） patients had grade I and II disease. During follow-up （median 66 months）, 27 patients （17.9%） had tumor recurrence and 18 （11.9%） died of bladder cancer. In the univariate analysis, the CSS and RFS curves between T2 and T3 patients showed no significant difference （P=-0.756 and 0.354, respectively）. Multivariate Cox regression showed that histological classification and grade were independent predictors for CSS, while grade was the sole independent predictor for RFS. Conclusions For this group of Chinese patients, perivesical fat invasion did not demonstrate a statistically significant difference in prognosis between T2 and T3 patients. Nontransitional cell carcinoma （non-TCC） and high-grade patients had short CSS, and patients with high-qrade tumor had higher recurrent risk.