Efficient Synthesis of Beraprost Sodium

An efficient and straightforward synthesis ofberaprost sodium was developed with dicyclopentadiene as a starting material, a one-pot reaction product 5 as key intermediate and the Prins reaction and the Homer-Wadsworth-Emmons reaction as key steps. The structures of the key intermediate and the targ...

Full description

Saved in:
Bibliographic Details
Published inChemical research in Chinese universities Vol. 32; no. 4; pp. 581 - 585
Main Authors Wang, Yue, Hou, Dalong, Lü, Haoze, Zhang, Baozhen, Wang, Ensi
Format Journal Article
LanguageEnglish
Published Changchun Jilin University and The Editorial Department of Chemical Research in Chinese Universities 01.08.2016
Subjects
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Homer
Inorganic Chemistry
Organic Chemistry
Physical Chemistry
Prins反应
原料合成
双环戊二烯
反应产物
钠
高效合成
高效液相色谱法
Horner-Wadsworth-Emmons reaction
Prins reaction
Beraprost sodium
One-pot reaction
Online AccessGet full text

Cover

More Information
Summary:An efficient and straightforward synthesis ofberaprost sodium was developed with dicyclopentadiene as a starting material, a one-pot reaction product 5 as key intermediate and the Prins reaction and the Homer-Wadsworth-Emmons reaction as key steps. The structures of the key intermediate and the target compound were confirmed by 1H NMR, 13C NMR and MS. The purity of beraprost sodium identified by high performance liquid chromatography（HPLC） was identical to that of Japanese Pharmacopoeia（16th）. This development will be used for the industrial synthesis of beraprost sodium.
Bibliography:Beraprost sodium; One-pot reaction; Prins reaction; Homer-Wadsworth-Emmons reaction
22-1183/O6
An efficient and straightforward synthesis ofberaprost sodium was developed with dicyclopentadiene as a starting material, a one-pot reaction product 5 as key intermediate and the Prins reaction and the Homer-Wadsworth-Emmons reaction as key steps. The structures of the key intermediate and the target compound were confirmed by 1H NMR, 13C NMR and MS. The purity of beraprost sodium identified by high performance liquid chromatography（HPLC） was identical to that of Japanese Pharmacopoeia（16th）. This development will be used for the industrial synthesis of beraprost sodium.
ISSN:1005-9040
2210-3171
DOI:10.1007/s40242-016-6093-7