NR4A3 fusion molecular profile change pathological diagnosis? A case report

•Acinic cell carcinoma may be misdiagnosed for other salivary gland cancers. When the pathological diagnosis is not clear, for example in those cases showing a high-grade transformation, merging histopathology with molecular profile analysis allows a definitive and precise diagnosis.•Molecular analy...

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Bibliographic Details
Published inOral oncology Vol. 131; p. 105964
Main Authors Pellegrini, Ilaria, Quattrone, Pasquale, Dagrada, Gianpaolo, Vischioni, Barbara, Orlandi, Ester, Colombo, Elena, Licitra, Lisa, Locati, Laura D.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.08.2022
Subjects
Acinic cell carcinoma
Case report
Molecular profile
NR4A3
Molecular profile
Case report
NR4A3
Acinic cell carcinoma
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Summary:•Acinic cell carcinoma may be misdiagnosed for other salivary gland cancers. When the pathological diagnosis is not clear, for example in those cases showing a high-grade transformation, merging histopathology with molecular profile analysis allows a definitive and precise diagnosis.•Molecular analyses of salivary gland cancers have become of the utmost importance. In this context, NR4A3 gene translocation has been recently reported as highly specific and sensitive for acinic cell carcinoma diagnosis and might help the differential diagnosis, especially in cases with high-grade transformation.•Referring patients with rare cancers to specialized centers where the samples can be thoroughly analyzed by dedicated pathologists is essential to achieve the correct pathological diagnosis, and allow a timely and tailored treatment.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2022.105964