Unusual Instance of Primary Diffuse Large B-cell Lymphoma of the Colon

Diffuse large B-cell lymphoma (DLBCL) commonly affects the gastrointestinal (GI) tract, although primary DLBCL rarely occurs in the colon. Primary colorectal lymphoma is a surprisingly rare diagnosis, accounting for a minute percentage of GI lymphomas and colorectal malignancies. We present an inter...

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Published inCurēus (Palo Alto, CA) Vol. 15; no. 3; p. e36083
Main Authors Kiamos, Amy, Streit, Spencer G, Karan, Abhinav, Boldig, Kimberly, Attarha, Barrett O, Kahn, Zoobia, Omman, Reeba, Schey, Ron, Gharia, Bharatsinh
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 13.03.2023
Cureus
Subjects
Abdomen
Anemia
Blood
Chemotherapy
Colon
Colorectal cancer
Creatinine
Disease
Emergency medical care
Epstein-Barr virus
Gastroenterology
Hematology
Hemoglobin
HIV
Human immunodeficiency virus
Immune system
Laboratories
Lupus
Lymphatic system
Lymphoma
Medical prognosis
Monoclonal antibodies
Multiple myeloma
Neutropenia
Oncology
Patient admissions
Transplants & implants
Ulcers
extranodal lymphomas
diffuse large b cell lymphoma (dlbcl)
extranodal diffuse large b-cell lymphoma
colorectal cancer
primary colorectal cancer
non-hodgkin’s lymphomas
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Summary:Diffuse large B-cell lymphoma (DLBCL) commonly affects the gastrointestinal (GI) tract, although primary DLBCL rarely occurs in the colon. Primary colorectal lymphoma is a surprisingly rare diagnosis, accounting for a minute percentage of GI lymphomas and colorectal malignancies. We present an interesting case of an immunocompromised young adult female who was diagnosed with DLBCL confined to a cecum polyp after she underwent a colonoscopy for a GI bleed. The lymphoma presented endoscopically as a semi-sessile polyp in the cecum that was successfully removed. The patient was treated with appropriate therapy of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP).
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.36083